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© Research
Event

Department seminar by Professor David Traver, University of California San Diego: “Developmental regulation of hematopoietic stem cells”

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
16
Mar 2018
Time
11:00:00
25 Rue du Dr Roux, Paris, France
Address
Building: Monod Room: Amphi Monod
Location
2018-03-16 11:00:00 2018-03-16 00:00:00 Europe/Paris Department seminar by Professor David Traver, University of California San Diego: “Developmental regulation of hematopoietic stem cells” All mature blood cell types in the adult animal arise from hematopoietic stem cells (HSCs). The developmental cues regulating HSC ontogeny are incompletely understood, as is the role of Wnt/b-catenin signaling in the process. […] 25 Rue du Dr Roux, Paris, France Philippe Herbomel philippe.herbomel@pasteur.fr

About

All mature blood cell types in the adult animal arise from hematopoietic stem cells (HSCs). The developmental cues regulating HSC ontogeny are incompletely understood, as is the role of Wnt/b-catenin signaling in the process. Using zebrafish, we have demonstrated that Wnt signaling is required to direct an amplification of nascent HSCs in the aorta. Wnt9a is specifically required for this process, and cannot be replaced by other canonical Wnt ligands. This is unusual for Wnt signaling, and we have now identified the receptor on HSC precursors that underlies this specificity. Our results support a general paradigm where early signaling events, including highly specific Wnt interactions, prime HSCs for later developmental processes.

 

Location

Building: Monod
Room: Amphi Monod
Address: 25 Rue du Dr Roux, Paris, France