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Groupe de Réflexion SIDA (GRS) meeting: “Humanized mice models for HIV studies”

BDCS Department seminar by Dr. Stéphane Nédelec, Stem cells in neurodevelopment and diseases team, Institut du fer à moulin Inserm, UPMC, Paris

© Research

Event

BDCS Department seminar by Professor Christian Klämbt, University of Münster, Institute of Neuro- and Behavioral Biology, Germany

Team: Structures and signals in the neurogenic niche

Department of: Developmental and Stem Cell Biology

Member: Pauline Speder

Scientific Fields

Diseases

Organisms

Applications

Technique

Date

01

Jun 2018

Time

11:00:00

25 Rue du Dr Roux, Paris, France

Address

Building: Monod

Location

2018-06-01 11:00:00 2018-06-01 00:00:00 Europe/Paris BDCS Department seminar by Professor Christian Klämbt, University of Münster, Institute of Neuro- and Behavioral Biology, Germany “Brain, Barriers, and Behavior in Drosophila” Abstract: Glial cells are an essential component required for the functionality of all complex nervous systems. In lower vertebrates and invertebrates, glial cells establish the blood-brain barrier and […] 25 Rue du Dr Roux, Paris, France Pauline Speder pauline.speder@pasteur.fr

About

“Brain, Barriers, and Behavior in Drosophila”

Abstract: Glial cells are an essential component required for the functionality of all complex nervous systems. In lower vertebrates and invertebrates, glial cells establish the blood-brain barrier and therefore establish the metabolic interface with the outside world. Next to metabolic support, glial cells guarantee ion homeostasis within the brain and are able to modulate synaptic functions by the regulation of neurotransmitter homeostasis. To decipher the molecular mechanisms underlying complex glial functions we are using the Drosophila nervous system as a model. Flies have a relatively low number of glial cells which can be manipulated individually using a well-equipped genetic tool box. Here I will focus on the establishment and maintenance of the blood-brain barrier and novel long-distance modulating functions of glial cells associated with the neuropil, the dendritic meshwork harboring all CNS synapses. Surprisingly, many of these functions appear conserved and are also found in the human brain.

Location

Building: Monod
Address: 25 Rue du Dr Roux, Paris, France

Published on: 22 May 2018

(function($) { /* * render_map * * This function will render a Google Map onto the selected jQuery element * * @type function * @date 8/11/2013 * @since 4.3.0 * * @param $el (jQuery element) * @return n/a */ function render_map( $el ) { var MY_MAPTYPE_ID = 'custom_style'; var featureOpts = [{"stylers":[{"hue":"#0088ff"}]}]; var styledMapOptions = { name: 'Custom Style' }; var customMapType = new google.maps.StyledMapType(featureOpts, styledMapOptions); // var var $markers = $el.find('.marker'); // vars var args = { zoom : 16, scrollwheel : false, center : new google.maps.LatLng(0, 0), mapTypeId : google.maps.MapTypeId.ROADMAP, mapTypeId : MY_MAPTYPE_ID }; // create map var map = new google.maps.Map( $el[0], args); map.mapTypes.set(MY_MAPTYPE_ID, customMapType); // add a markers reference map.markers = []; // add markers $markers.each(function(){ add_marker( $(this), map ); }); // center map center_map( map ); } /* * add_marker * * This function will add a marker to the selected Google Map * * @type function * @date 8/11/2013 * @since 4.3.0 * * @param $marker (jQuery element) * @param map (Google Map object) * @return n/a */ function add_marker( $marker, map ) { // var var latlng = new google.maps.LatLng( $marker.attr('data-lat'), $marker.attr('data-lng') ); //var image = 'https://research.pasteur.fr/wp-content/themes/biologyx2/images/logomap.png'; var myIcon = new google.maps.MarkerImage('https://research.pasteur.fr/wp-content/themes/biologyx2/images/map-pin.png', null, null, null, new google.maps.Size(32,32)); // create marker var marker = new google.maps.Marker({ position : latlng, map : map, icon : myIcon }); // add to array map.markers.push( marker ); // if marker contains HTML, add it to an infoWindow if( $marker.html() ) { // create info window var infowindow = new google.maps.InfoWindow({ content : $marker.html() }); // show info window when marker is clicked google.maps.event.addListener(marker, 'click', function() { infowindow.open( map, marker ); }); } } /* * center_map * * This function will center the map, showing all markers attached to this map * * @type function * @date 8/11/2013 * @since 4.3.0 * * @param map (Google Map object) * @return n/a */ function center_map( map ) { // vars var bounds = new google.maps.LatLngBounds(); // loop through all markers and create bounds $.each( map.markers, function( i, marker ){ var latlng = new google.maps.LatLng( marker.position.lat(), marker.position.lng() ); bounds.extend( latlng ); }); // only 1 marker? if( map.markers.length == 1 ) { // set center of map map.setCenter( bounds.getCenter() ); map.setZoom( 15 ); } else { // fit to bounds map.fitBounds( bounds ); } } /* * document ready * * This function will render each map when the document is ready (page has loaded) * * @type function * @date 8/11/2013 * @since 5.0.0 * * @param n/a * @return n/a */ $(document).ready(function(){ $('.acf-map').each(function(){ render_map( $(this) ); }); }); })(jQuery);