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© Research
Event

BDCS Department seminar by Professor Christian Klämbt, University of Münster, Institute of Neuro- and Behavioral Biology, Germany

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
01
Jun 2018
Time
11:00:00
25 Rue du Dr Roux, Paris, France
Address
Building: Monod Room: Amphi Monod
Location
2018-06-01 11:00:00 2018-06-01 00:00:00 Europe/Paris BDCS Department seminar by Professor Christian Klämbt, University of Münster, Institute of Neuro- and Behavioral Biology, Germany “Brain, Barriers, and Behavior in Drosophila” Abstract: Glial cells are an essential component required for the functionality of all complex nervous systems. In lower vertebrates and invertebrates, glial cells establish the blood-brain barrier and […] 25 Rue du Dr Roux, Paris, France Pauline Speder pauline.speder@pasteur.fr

About

“Brain, Barriers, and Behavior in Drosophila”

Abstract: Glial cells are an essential component required for the functionality of all complex nervous systems. In lower vertebrates and invertebrates, glial cells establish the blood-brain barrier and therefore establish the metabolic interface with the outside world. Next to metabolic support, glial cells guarantee ion homeostasis within the brain and are able to modulate synaptic functions by the regulation of neurotransmitter homeostasis. To decipher the molecular mechanisms underlying complex glial functions we are using the Drosophila nervous system as a model. Flies have a relatively low number of glial cells which can be manipulated individually using a well-equipped genetic tool box. Here I will focus on the establishment and maintenance of the blood-brain barrier and novel long-distance modulating functions of glial cells associated with the neuropil, the dendritic meshwork harboring all CNS synapses. Surprisingly, many of these functions appear conserved and are also found in the human brain.

 

 

Location

Building: Monod
Room: Amphi Monod
Address: 25 Rue du Dr Roux, Paris, France