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About

Dr. Musette is Professor of Dermatology (PU-PH) at Rouen University Hospital.

Research Themes :

  • Rituximab (anti-CD20) for pemphigus patients (an auto-immune disease) clinical trials and biological research
  • Pathophysiology of DRESS (Drug reaction with eosinophilia and systemic symptoms): role of viral reactivation
  • Role of Toll Like Receptors in murine lupus

Medico-Scientific Career

  • Internat de L’Ile de France 23e (1992)
  • Foreign Medical Graduate Examination in the Medical Sciences (1992)
  • CESAM (1993)
  • DES Dermatology (1997)
  • MD PARIS VII (1997)
  • DESC Immunology (1999) 
  • DESC cancerology (VAE) (2013)

Scientific trial

  • Master of Biochemistry PARIS V 1990
  • PhD of Immunology PARIS VI 1996. Pr Ph. Kourilsky. Institut Pasteur
  • HDR PARIS V 2001

Collective activities

  • President “French Society of research in Dermatology” (2002-2004)
  • President “Scientific council of the French Society of Dermatology ” (2004-2006)
  • President “National program of Dermatology INSERM” (2006-2008) 
  • Board member of the European Society for Dermatological Research (2008-2012)
  • Responsible for the Dermatology certification for French North and Ouest area (2014-     )
  • Head of GATC-Pharma and Clonomab: R and D consulting, drug development

Member of : Société Française d’Immunologie, Société Française de Dermatologie, Société Française de Recherche en Dermatologie, European society for dermatological Research, European Academy of Dermato-Venerology, American Academy of immunology.

Publications (recent)

  • Human regulatory B cells combine phenotypic and genetic hallmarks with a distincdifferentiation fate. Lin W, Cerny D, Chua E, Duan K, YI JT, Shadan NB, Lum J, Maho-Vaillant M, Zolezzi F, Wong SC, larbi A, Fink K, Musette P, Poidinger M, Calbo S. J Immunol. 2014 ; 193: 2258-66
  • Direct Toll-Like Receptor 8 signaling increases the functional avidity of human CD8+ T lymphocytes generated for adoptive T cell therapy strategies. Chatillon JF, Hamieh M, Bayeux F, Abasq C, Fauquembergue E, Drouet A, Guisier F, Latouche JB, Musette P.     Immunol Inflam Dis. 2015 ; 3 :1-13
  • soluble alpha-enolase activates monocytes by CD14 dependent TLR4 signaling pathway and exhibits a dual function. Guillou C, Freret M, Fondard E, Derambure C, Avenel G, Golinski ML, Verdet M, Boyer O, Caillot F, Musette P, Lequerre T, Vittecoq O. Sci Rep. 2016 6: 23796. on line
  •  New approaches to investigate drug –induced hypersensitivity Ogese MO, Ahmed S, Alfirevic A, Betts CJ, Dickinson A, Faulkner L, French NS, Gibson A, Hirschfield GM, Kammuller ME, Meng X, Martin SF, Musette P, Norris A, Pirmohamed M, Park BK, Purcell AW, Spraggs CF, Whritenour J, Naisbitt DJ. Chem Res Toxicol 2016 in press
  • First line use of Rituximab combined with short term prednisone versus corticoid alone in the treatment of patients with pemphigus: a prospective multicenter randomized trial Joly P, Maho-Vaillant M, Prost- Squarcioni C, Hebert V, Houivet E, Calbo S, Caillot F, Golinski ML, Labeille B, Picard-Dahan C, Paul C, Richard MA, Bouaziz JD, Duvert-Lehembre S, Bernard P, Caux F, Alexandre M, Ingen-Housz-Oro S, Vabres P, Delaporte E, Quereux G, Dupuy A, Debarbieux S, Avenel-Audran M, D’Ican M, Bedane C, Beneton N, Jullien D, Dupin N, Misery L, Machet L, Beylot-Barry M, Dereure O, Sassolas B, Benichou J, Musette P  The Lancet 2016 on line