Antoine Toubert

Phone : +33142494640 Location : PARIS, France Course and current status 2002-present Full Professor of Immunology and Hospital Practionner (PU-PH), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Louis and Université Paris Diderot, Sorbonne Paris Cité, Paris, France. 2002- present Head of a research group at INSERM U662 (2002-2008) and UMRS 940 (2008-present). Scientific summary I am presently (since 2002) Full Professor of Immunology (Université Paris-Diderot, Sorbonne Paris Cité). In addition to teaching duties, I am in charge of the Immunology laboratory hospital at Hôpital Saint-Louis (routine follow-up of acquired immunodeficiencies in HIV, organ and bone marrow transplantation, Autoimmunity, monitoring of Biotherapies) and of the Translational Research Unit in Immunobiology of Transplantation and Hematology. This is part of the Immunology and Histocompatibility laboratory (D. Charron). We are closely connected with the clinical departments of Hematology-Bone Marrow Transplantation (G. Socié), Hematology (H. Dombret), Gastroenterology (M. Allez), Dermatology (M. Bagot). I am also leading a research group entitled “Immunopathology and Immune intervention in Humans” at INSERM U940 (Institut Universitaire d’Hématologie). Main topics are: Immunobiology of Hematopoietic Stem Cell Transplantation in Humans (HSCT) Immune reconstitution of T lymphocyte populations: thymic function and HSCT outcome, mechanisms of thymic GVHD in Humans, viral-specific immune functions. NK development and homeostasis in an allogeneic environment. Impact of HLA/KIR mismatches and KIR genotyping on outcome. Leukemic specific-immune responses Role of NK lymphocytes and especially NKG2D ligands (MIC, ULBP) in myeloid malignancies (CML, AML) and lymphomas. Immune responses in inflammatory bowel diseases: definition of CD4+NKG2D+ T-cells, a lymphocyte population with a Th1/Th17 profile with a potential pathogenic role in Crohn’s disease.