Center for Translational Science

This service aims to guide researchers interested in developing clinical trials or a research project involving human samples or human data. Scientists submit their project to  crt-guichetunique@pasteur.fr and their projects are evaluated by representatives from the Medical Research Department as well as the Legal department. Guichet Unique provides researchers with the necessary information to initiate their translational research projects at Institut Pasteur and to anticipate appropriate actions, in particular those relating to regulatory requirements. This ensures optimal evaluation of projects according to their typology and the associated risks, and that support for researchers can be tailored accordingly.

NB: Research on human samples or personal data is subject to compliance with regulations and good practices.

The Institut Pasteur signed a framework agreement with Parisian hospitals (AP-HP) as well as Hôpital Sainte-Anne and a partnership agreement with Hôpital Necker to reinforce translational research collaborations. Importantly, the CRT funds clinicians at various stages of their careers (residency, professor) to develop projects at Institut Pasteur.

The CRT organizes a series of scientific events in order to facilitate interactions between clinicians and researchers and to increase awareness of medical research at Institut Pasteur. In the context of the ‘Quart d’heure Médecine’, invited clinicians give medical talks (in French ; videotaped) at Institut Pasteur. In a complementary fashion, in the ‘Quart d’heure Science’, Pasteur scientists present their results during meetings during staff meetings at Paris hospitals. The latter can be coupled to more extensive stays within clinical services ‘des souris et des hommes’. Finally, ‘Storms’ are a half-day forum that provide scientists and physicians to confront ideas on specific topics (neurostorm, cancerostorm, ageingstorm). The Journée de la Recherche Translationnelle is an annual one-day symposium that highlights Institut Pasteur activities in a particular area of translational research. Since 2016, the CRT is an active member to the “Ateliers de Giens”, which provide key links with industrials.

Pasteur Network gathers 33 institutes in 25 countries over the 5 continents and has a major role in public health, research, teaching as well as in epidemic surveillance.

After an evaluation of the current clinical research capacity in 6 institutes of Pasteur Network (IP Cambodia, IP Cameroon, IP French Guyana, IP Ivory Coast, IP Madagascar, IP Senegal, IP Paris, IP Tunisia) both global and specific actions have been put in place to support research on infectious diseases. In this context new software to collect clinical data in remote areas (REDCap) has  been put in place. The CRT is co-leader of a workpackage in the ALERRT project, funded by a European call (EDCTP), an African coalition for epidemic research, response and training. Targeted actions consisted in the implementation of clinical research projects on infectious diseases.

In order to better answer tomorrow’s health challenges, patients and research participants should be more involved in the research process. This is also a prerequisite of the Horizon 2020 European funding program. The CRT has organized events with INSERM, Institut Curie, National Health Service (UK), Vrije university (Netherland), patient’s organisations … in order to benchmark the practices in other French and European institutions.