About

The Center for translational science is one of the transversal centers that was inaugurated in September 2014. It is part of the medical research department together with the Medical Center and the National reference Centers. The CRT aims to facilitate links between researchers of the Institut Pasteur International Network and clinicians in order to develop more projects related to human health. The center was initially directed by Matthew Albert.  In 2015, a team comprised by Stanislas Pol, Odile Gelpi and James di Santo were named as co-Directors. It is now directed by Isabelle Cailleau.

Missions
  • Support fundamental and clinical research that will accelerate the translation of scientific breakthroughs into improved human health
  • Provide access and training on state-of-the-art technical cores
  • Support clinical trial development in a regulatory environment secure for both researchers and Institution in accordance with institutional agreements (WHO and ethics charter)
  • Inspire and coordinate new translational research projects through expert project management and coordinated activities with academic hospitals and industrial partners
The center consists of :

  • Clinical core services (activities supported by the former Pole integré de recherche Clinique, PIRC)
  • Biobanking activity and healthy volunteer cohort access (coordinated by ICAReB)
  • Technical core for translational science supported by the Cytometry and Biomarker UTechS
Actions

The center improves access to patient and healthy volunteers samples for scientific community and helps to overcome burdensome regulatory procedures associated with translational and clinical research through the development of the “guichet unique“. The Center attracts clinicians at Institut Pasteur and facilitates partnerships with hospitals or with the Medical Center of the Institut Pasteur. The CRT organizes a series of scientific events in order to facilitate interactions between clinicians and researchers and to increase awareness of medical research at Institut Pasteur (Journée de la recherche translationnelle, Quart d’heure Pasteur – Médecine, Quart d’heure Pasteur – Sciences). The CRT also supports clinical research in the Institut Pasteur International Network (Pasteur Network). The CRT developp stronger links with patient’s associations. It supports scientists for translational research fundraising actions and provides greater exposure of Institutional translational research activities. Over the next years, the Center aims to develop an academic interdisciplinary program in Translational research.

The center has obtained a quality certification since May 2017 in order to improve its efficiency as well as the satisfaction of its users.

More information (download)

Provide integrated support for translational research

This service aims to guide researchers interested in developing clinical trials or a research project involving human samples or human data. Scientists submit their project to  crt-guichetunique@pasteur.fr and their projects are evaluated by representatives from the Medical Research Department as well as the Legal department. Guichet Unique provides researchers with the necessary information to initiate their translational research projects at Institut Pasteur and to anticipate appropriate actions, in particular those relating to regulatory requirements. This ensures optimal evaluation of projects according to their typology and the associated risks, and that support for researchers can be tailored accordingly.

 

Attract clinicians to the campus through medical partnerships

The Institut Pasteur signed a framework agreement with Parisian hospitals (AP-HP) as well as Hôpital Sainte-Anne and a partnership agreement with Hôpital Necker to reinforce translational research collaborations. Importantly, the CRT funds clinicians at various stages of their careers (residency, professor) to develop projects at Institut Pasteur.

Facilitate the emergence and visibility of translational research

The CRT organizes a series of scientific events in order to facilitate interactions between clinicians and researchers and to increase awareness of medical research at Institut Pasteur. In the context of the ‘Quart d’heure Médecine’, invited clinicians give medical talks (in French ; videotaped) at Institut Pasteur. In a complementary fashion, in the ‘Quart d’heure Science’, Pasteur scientists present their results during meetings during staff meetings at Paris hospitals. The latter can be coupled to more extensive stays within clinical services ‘des souris et des hommes’. Finally, ‘Storms’ are a half-day forum that provide scientists and physicians to confront ideas on specific topics (neurostorm, cancerostorm, ageingstorm). The Journée de la Recherche Translationnelle is an annual one-day symposium that highlights Institut Pasteur activities in a particular area of translational research. Since 2016, the CRT is an active member to the “Ateliers de Giens”, which provide key links with industrials.

Developping clinical research in the International Network

carte réseauPasteur Network gathers 33 institutes in 25 countries over the 5 continents and has a major role in public health, research, teaching as well as in epidemic surveillance.

After an evaluation of the current clinical research capacity in 6 institutes of Pasteur Network (IP Cambodia, IP Cameroon, IP French Guyana, IP Ivory Coast, IP Madagascar, IP Senegal, IP Paris, IP Tunisia) both global and specific actions have been put in place to support research on infectious diseases. In this context new software to collect clinical data in remote areas (REDCap) has  been put in place. The CRT is co-leader of a workpackage in the ALERRT project, funded by a European call (EDCTP), an African coalition for epidemic research, response and training. Targeted actions consisted in the implementation of clinical research projects on infectious diseases.

Develop stronger links with patient’s associations

In order to better answer tomorrow’s health challenges, patients and research participants should be more involved in the research process. This is also a prerequisite of the Horizon 2020 European funding program. The CRT has organized events with INSERM, Institut Curie, National Health Service (UK), Vrije university (Netherland), patient’s organisations … in order to benchmark the practices in other French and European institutions.

Projects