The Center for translational science is one of the transversal centers that was inaugurated in September 2014. The CRT aims to facilitate links between researchers of the Institut Pasteur International Network and clinicians in order to develop more projects related to human health. The center was initially directed by Matthew Albert.  In 2015, a team comprised by Stanislas Pol and Odile Gelpi  were named as co-Directors and later joined by James di Santo. It is now directed by Bruno Hoen and Isabelle Cailleau.

  • Support fundamental and clinical research that will accelerate the translation of scientific breakthroughs into improved human health
  • Provide access and training on state-of-the-art technical cores
  • Support clinical trial development in a regulatory environment secure for both researchers and Institution in accordance with institutional agreements (WHO and ethics charter)
  • Inspire and coordinate new translational research projects through expert project management and coordinated activities with academic hospitals and industrial partners
The center consists of :

  • Clinical core services (activities supported by the former Pole integré de recherche Clinique, PIRC)
  • Biobanking activity and healthy volunteer cohort access (coordinated by ICAReB)
  • Technical core for translational science supported by the Cytometry and Biomarker UTechS

The center improves access to patient and healthy volunteers samples for scientific community and helps to overcome burdensome regulatory procedures associated with translational and clinical research through the development of the open desk. The Center attracts clinicians at Institut Pasteur and facilitates partnerships with hospitals or with the Medical Center of the Institut Pasteur. The CRT organizes a series of scientific events in order to facilitate interactions between clinicians and researchers and to increase awareness of medical research atInstitut Pasteur (Journée de la recherche translationnelle, Quart d’heure Pasteur – Médecine, Quart d’heure Pasteur – Sciences). The CRT also developps clinical research in the Institut Pasteur International Network through the INCREASE initiative. The CRT developp stronger links with patient’s associations. It supports scientists for translational research fundraising actions and provides greater exposure of Institutional translational research activities. Over the next years, the Center aims to develop an academic interdisciplinary program in Translational research. The Center coordinates research transversal group on ageing and longevity. The center has obtained a quality certification since May 2017 in order to improve its efficiency as well as the satisfaction of its users.

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Provide integrated support for translational research

The CRT ‘Open Desk’ (OD) was launched in January 2017. This service aims to guide researchers interested in developing a research project involving human samples or data. Each Thursday, OD reunites representatives from the three key CRT structures (clinical core, technology core and ICAReB) as well as the legal department and the ethics service (and if needed, the international and technology transfer departments). OD provides researchers with the necessary information to initiate their translational research projects at Institut Pasteur and to anticipate appropriate actions, in particular those relating to regulatory requirements.

Attract clinicians to the campus through medical partnerships

The Institut Pasteur signed a framework agreement with Parisian hospitals (AP-HP) as well as Hôpital Sainte-Anne and more recently, a partnership agreement with Hôpital Necker to reinforce translational research collaborations. Importantly, the CRT funds clinicians at various stages of their careers (residency, professor) to develop projects at Institut Pasteur.

Facilitate the emergence and visibility of translational research

The CRT organizes a series of scientific events in order to facilitate interactions between clinicians and researchers and to increase awareness of medical research at Institut Pasteur. In the context of the ‘Quart d’heure Médecine’, invited clinicians give medical talks (in French ; videotaped) at Institut Pasteur. In a complementary fashion, in the ‘Quart d’heure Science’, Pasteur scientists present their results during meetings during staff meetings at Paris hospitals. The latter can be coupled to more extensive stays within clinical services. Finally, ‘Storms’ are a half-day forum that provide scientists and physicians to confront ideas on specific topics (neurostorm, cancerostorm, ageingstorm). The Journée de la Recherche Translationnelle is an annual one-day symposium that highlights Institut Pasteur activities in a particular area of translational research. Since 2016, the CRT is an active member to the “Ateliers de Giens”, which provide key links with industrials.

Developping clinical research in the International Network

carte réseau Increase (International Network Clinical ResEArch Sustainable InitiativEs) The Institut Pasteur International Network (IPIN) gather 33 institutes in 25 countries over the 5 continents. The IPIN has a major role in public health, research, teaching as well as in epidemic surveillance. The goal of INCREASE is to facilitate clinical research in the Institut Pasteur International Network. This intiative is driven by IP Cambodia, IP Cameroon, IP French Guyana, IP Ivory Coast, IP Madagascar, IP Senegal, IP Paris, IP Tunisia and will be extended to the whole network in the future. In this context a new software to collect clinical data in remote areas (REDCap) has been put in place. The CRT is co-leader of a workpackage in the ALERRT project, funded by a European call (EDCTP), an African coalition for epidemic research, response and training. Futhermore, the CRT coordinates the implementation of clinical research projects on infectious diseases. These actions are led together with the technology transfer, international, IT & legal departments as well as with all researchers willing to implement clinical research projects with the RIIP. This initiative is coordinated by Fabien Taieb. Join the community on our collaborative website.

Develop stronger links with patient’s associations

In order to better answer tomorrow’s health challenges, patients should be more involved in the research process. This is also a prerequisite of the Horizon 2020 European funding program. The CRT has organized events with INSERM, Institut Curie, National Health Service (UK), Vrije university (Netherland), patient’s organisations … in order to benchmark the practices in other French and European institutions. IP has signed in June 2018 a convention with Thellie, a crowdfunding platform, that allows patients to facilitate research projects of interest.