The Center for Animal Resources and Research (C2RA) is one of the three components of the Technology and Scientific Programs Department. The C2RA meets the needs in animal models of Institut Pasteur research groups and gathers the Central Animal Facility , the Center for Mouse Genetics Engineering (CIGM) and the Center for Production and Infection of Anopheles (CEPIA).
Additional resources for animal models, independent of the C2RA, are also available including the Zebrafish Projects Hub (see below).
The Center for Animal Resources and Research is under the scientific responsibility of Christophe d’Enfert and the administrative and operational responsibility of Anna Kehres.
Central Animal Facility
Head: Christophe Joubert
The Central Animal Facility provides the research teams with the necessary infrastructure to use animal models in the best ethical and regulatory conditions. 15.000 cages for rodents are available with different confining levels. The use of germ-free, gnotobiotic or pathogen-free mice is possible as well as the maintenance and preservation of transgenic lines. Small animal imaging tools are available.
Centre for Murine Engineering and Genetics
Head: Francina Langa-Vives
The Center forMouse Genetics Engineering (CIGM) is Institut Pasteur’s core facility for animal transgenesis. CIGM produces new genetically modified murine models by random insertion, targeted replacement, and more recently by microinjection of specific nucleases (ZFN, TALE, and CRISPR/Cas9) upon request of the research units.
Center for the Production and Infection of Anopheles
Head: Patricia Baldacci
The Center for the Production and Infection of Anopheles (CEPIA) is a core facility dedicated to the mass production of mosquitoes of the Anopheles species. CEPIA allows the study of the interactions between Plasmodium, the malaria-causing parasite, and their mammalian or mosquito hosts.
The Zebrafish Projects Hub
Contact: Laure Bally-Cuif, Jean-Pierre Levraud, Emma Colucci
The Zebrafish Projects Hub (Zorgl’hub) aims to provide Institut Pasteur research groups with the possibility to conduct short term zebrafish trial projects,
– as a functional complement to existing projects using other models/cells
– to obtain proof of principle evidence to support grant applications.